ACP Partners With OpenEvidence to Integrate Clinical Guidelines Into AI Decision-Making

November 9, 2026 by matray

The American College of Physicians (ACP) announced a partnership with artificial intelligence platform OpenEvidence to integrate evidence-based clinical guidelines and peer-reviewed medical research into an AI-powered tool used by physicians at the point of care, a development that could have implications for clinical decision-making and medical professional liability.

Under the licensing agreement announced Nov. 9, OpenEvidence will incorporate ACP's clinical guidance and published research from Annals of Internal Medicine, the organization's peer-reviewed medical journal, into its clinical decision-support platform.

The collaboration is intended to give physicians access to authoritative medical evidence when evaluating diagnoses, treatment options and other clinical questions. OpenEvidence provides AI-generated responses supported by citations to medical literature, allowing physicians to review the underlying research.

ACP, the largest medical specialty organization in the United States, develops clinical guidelines, guidance statements and best-practice recommendations based on available scientific evidence. The organization represents approximately 163,000 members worldwide.

OpenEvidence, which is available free to verified U.S. clinicians, says its platform is used daily by a majority of U.S. physicians. Internal medicine is the platform's largest specialty, according to the company.

Jan K. Carney, MD, MPH, president of ACP, said the collaboration would help physicians access reliable clinical information while treating patients.

"Having access to trusted, evidence-based clinical guidance from ACP and peer-reviewed content from Annals of Internal Medicine where and when they need it can help physicians make more informed clinical decisions in real time and devote more time and attention to patient care," Carney said.

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